The morphinelike compound McDougall refers to is known as endomorphin 1, and his team studied whether peripheral administration of this endogenous ¿-opioid peptide could reduce knee joint pain.

A clinical trial of an experimental drug for treatment-resistant major depression finds that modulation of the endogenous opioid system may improve the effectiveness of drugs that target the action of ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky ...

Given how profound an influence opioids have on the world – for better or worse – scientists know surprisingly little about how these drugs actually work. A recent study led by researchers from ...

New research undertaken by American and Chinese researchers may pave the way for safer opioid painkillers, thanks to the use of cryo-electron microscopy (cryo-EM) to examine the detailed structures of ...

Everyone knows that stubbing your toe hurts. What makes it stop hurting is the body's main pain-blocking process - the natural production of opioids. Cognitive-based approaches found to reduce pain, ...

In a new study evaluating meditation for chronic lower back pain, researchers at University of California San Diego School of Medicine have discovered that men and women utilize different biological ...

Nearly impossible to measure, quantify, convey, pain is a truly mysterious human sensation. For the last 25 years in my life as a neurosurgeon, I have seen a lot of pain and suffering firsthand, so ...